Nyem rau qhov no yog qhov no yog koj tshaj tawm!

Genital Psoriasis: Cov txiaj ntsig ntawm Kev Tshawb Fawb Tshiab

Amgen hnub no tshaj tawm cov txiaj ntsig zoo tshaj plaws los ntawm kev sim DISCREET, Theem 3, multicenter, randomized, placebo-tswj, ob-dig muag txoj kev tshawb fawb los ntsuam xyuas qhov ua tau zoo ntawm Otezla® (apremilast) rau cov neeg laus uas muaj mob hnyav rau qhov chaw mos psoriasis thiab nruab nrab rau mob hnyav plaque psoriasis.

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Txoj kev tshawb no qhia tau hais tias qhov ncauj Otezla 30 mg ob zaug ib hnub twg tau ua tiav kev kho mob tseem ceeb thiab kev txhim kho tseem ceeb, piv nrog cov placebo, nyob rau hauv thawj qhov kawg ntawm kev hloov kho zoo li Tus Kws Kho Mob Ntiaj Teb Kev Ntsuas ntawm Genitalia (sPGA-G) cov lus teb (txhais tias yog sPGA-G qhab nia. ntawm qhov tseeb (0) lossis yuav luag meej (1) nrog tsawg kawg yog 2-point txo los ntawm qhov pib) ntawm lub lim tiam 16.      

Tsis tas li ntawd, tag nrho cov ntsiab lus thib ob kuj tau ntsib nrog cov ntsiab lus tseem ceeb thiab kev txhim kho tseem ceeb hauv Genital Psoriasis Itch Numerical Rating Scale (GPI-NRS) cov lus teb (txhais tau tias tsawg kawg yog 4-point txo los ntawm lub hauv paus hauv GPI-NRS cov qhab nia hauv Genital Psoriasis Cov tsos mob rau cov kev kawm uas tau qhab nia nruab nrab ntawm ≥ 4); cuam ​​tshuam lub cev qhov chaw (BSA) hloov los ntawm lub hauv paus; Dermatology Life Quality Index (DLQI) hloov los ntawm lub hauv paus; thiab static Physician's Global Assessment (sPGA) teb (txhais tau tias yog sPGA cov qhab nia ntawm qhov tseeb (0) lossis yuav luag pom tseeb (1) nrog tsawg kawg yog 2-point txo los ntawm lub hauv paus) ntawm lub lim tiam 16 nrog Otezla piv rau cov placebo.

Hom thiab tus nqi ntawm cov xwm txheej tsis zoo tshwm sim hauv qhov kev sim no tau ua raws li kev paub txog kev nyab xeeb ntawm Otezla. Feem ntau tshaj tawm cov xwm txheej tsis zoo uas tshwm sim tsawg kawg 5% ntawm cov neeg mob hauv ob pawg kho mob yog raws plab, mob taub hau, xeev siab thiab nasopharyngitis.

Cov neeg mob ua tiav ob qhov muag tsis pom kev ntawm qhov kev sim txuas ntxiv lossis hloov mus rau Otezla thaum lub sijhawm txuas ntxiv ntawm txoj kev tshawb fawb thiab yuav raug kho mus txog lub lim tiam 32. Txoj kev tshawb fawb tseem tab tom npaj ua tiav hauv thawj ib nrab xyoo 2022.

Cov ntsiab lus ntxaws ntxaws los ntawm 16-lub lim tiam ob-qhov muag tsis pom ntawm txoj kev tshawb no yuav raug xa mus rau kev nthuav qhia ntawm lub rooj sib tham kho mob yav tom ntej.

Hauv Teb Chaws Asmeskas, Otezla tau pom zoo rau kev kho mob ntawm cov neeg laus cov neeg laus uas muaj cov kab mob me me mus rau mob hnyav plaque psoriasis uas yog cov neeg sib tw rau kev kho mob los yog kev kho mob, cov neeg laus uas muaj mob caj dab psoriatic thiab rau cov neeg laus uas muaj mob qhov ncauj nrog rau Behçet's Disease. Txij li thaum nws thawj zaug tau pom zoo los ntawm FDA hauv 2014, Otezla tau raug tshuaj rau ntau tshaj 650,000 tus neeg mob thoob ntiaj teb nrog mob hnyav-rau-mob plaque psoriasis, mob caj dab psoriatic lossis Behçet's Disease.

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Hais txog qhov kev sau

Linda Hohnholz, tus sau eTN

Linda Hohnholz tau sau thiab kho cov lus txij li thaum pib ua haujlwm. Nws tau thov qhov kev txaus siab uas tsis txaus ntseeg rau qhov chaw xws li Hawaii Pacific University, Chaminade University, Hawaii Children's Discovery Center, thiab tam sim no TravelNewsGroup.

Cia ib saib