Kev kho tshiab tuaj yeem ncua kev nce qib ntawm Alzheimer's Disease

Moleac tshaj tawm qhov kev tso tawm ntawm ATHENE cov txiaj ntsig kev tshawb fawb, luam tawm hauv Phau Ntawv Xov Xwm ntawm American Medical Director Association (JAMDA).

Kev kho mob uas tuaj yeem ua rau qeeb ntawm AD thaum nws tau mus txog theem kho mob, tseem yog ib qho tseem ceeb tsis tau txais kev kho mob. NeuroAiD™ II tau pom tias muaj cov teebmeem modulatory ntawm amyloid precursor protein (APP) ua2 thiab kev hloov ntawm tau protein ntau mus rau hauv phosphorylated txawv txav thiab aggregated forms3, nrog rau cov neuro-regenerative thiab neuro-restorative zog4. Cov txiaj ntsig zoo ntawm NeuroAiD™ II ntawm kev ua haujlwm tsis txaus ntseeg twb tau pom nyob rau hauv kev raug mob ntawm lub hlwb5.

Txoj Kev Kho Mob Alzheimer's Disease nrog NEuroaid (ATHENE) Txoj Kev Kawm yog thawj txoj kev tshawb fawb los soj ntsuam kev nyab xeeb thiab kev ua tau zoo ntawm NeuroAiD™ II hauv cov neeg mob me thiab nruab nrab AD ruaj khov ntawm cov qauv kev kho mob.

ATHENE yog 6-hli randomized ob qhov muag tsis pom kev, kev sim tshuaj placebo-tswj tom qab los ntawm kev qhib daim ntawv txuas ntxiv ntawm NeuroAiD™ II kev kho mob rau lwm 6 lub hlis. 125 yam kev kawm los ntawm Singapore tau suav nrog hauv qhov kev sim, uas tau koom tes los ntawm Lub Chaw Memory Aging and Cognition Center, National University Health System, National Neuroscience Institute, thiab St. Luke's Hospital, Singapore.

• NeuroAiD™ II tau qhia txog kev nyab xeeb mus sij hawm ntev raws li kev kho mob ntxiv hauv AD uas tsis muaj kev nce ntxiv ntawm cov neeg mob uas muaj cov xwm txheej tsis zoo lossis cov xwm txheej tsis zoo.

• Kev pib ntxov ntawm NeuroAiD™ II tau muab kev txhim kho mus sij hawm ntev ntawm kev paub txog piv rau cov placebo (cov pab pawg pib lig) ntsuas los ntawm ADAS-cog, suav nrog qhov tseem ceeb ntawm 9 lub hlis, thiab txo qis qis dua lub sijhawm.

ATHENE txoj kev tshawb fawb tau txhawb nqa cov txiaj ntsig ntawm NeuroAiD™ II raws li kev nyab xeeb ntxiv rau kev kho mob rau tus qauv AD raws li txoj kev tshawb fawb pom tsis muaj pov thawj ntawm qhov tshwm sim tsis zoo ntawm MLC901 thiab placebo. Kev soj ntsuam qhia txog qhov muaj peev xwm ntawm MLC901 hauv kev ua kom qeeb ntawm AD kev loj hlob uas zoo ib yam nrog kev tshawb fawb txog kev kho mob thiab kev kho mob yav dhau los, ua rau nws muaj kev cog lus rau cov neeg mob AD. Cov txiaj ntsig no xav tau kev pom zoo ntxiv hauv kev tshawb fawb loj thiab ntev dua.                                                         

Ib lo lus los ntawm Tus Thawj Saib Xyuas Kev Tshawb Fawb

"Alzheimer's Disease yog feem ntau ua rau dementia, suav txog 60-80% ntawm cov neeg mob. Txog rau tam sim no kev pom zoo ntawm aducanumab los ntawm FDA, tsis muaj kab mob hloov kho rau Alzheimer's Disease, thiab cov kev kho mob tam sim no nrhiav kev ncua ib ntus ntawm cov tsos mob dementia thiab txhim kho lub neej zoo rau cov neeg Alzheimer's thiab lawv cov neeg saib xyuas. Yog li ntawd, yuav tsum tau muab cov neeg mob thiab lawv cov neeg zov me nyuam nkag mus rau kev kuaj mob thiab kho tshiab.

Cov txiaj ntsig tau txais txiaj ntsig ntawm ATHENE txoj kev tshawb fawb yuav tsum tau nkag siab tias yog ib feem ntawm Alzheimer's Disease tshuaj txoj kev loj hlob pipeline hloov ntawm cov tsos mob mus rau cov kab mob hloov kho. Txoj kev tshawb no thiab lwm yam kev kho mob uas muaj peev xwm yuav tsum tau soj ntsuam nruj los ntawm kev sim tshuaj ntsuam xyuas zoo. "

Xibfwb Christopher Chen

Tus Thawj Coj, Memory Aging and Cognition Center, National University Health System thiab Associate Professor, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore.

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