Kev sim tshiab rau Metastatic Castration-Resistant Prostate Cancer

"Qhov pib ntawm qhov kev sim ua ke no nrog Astellas yog lub sijhawm dej ntws rau ESSA thaum peb tshawb xyuas cov txiaj ntsig kho mob muaj peev xwm ntawm inhibiting androgen receptor los ntawm ob txoj hauv kev ywj pheej hauv kev kho mob ntawm cov neeg mob mCRPC uas tseem tsis tau txais kev kho mob nrog cov tshuaj antiandrogen thib ob. tshuaj, ”said Dr. David. R. Parkinson, Tus Thawj Coj Tus Thawj Coj, ESSA Pharma Inc. "Kev sib koom ua ke peb ob txoj kev kho mob yuav ua rau tib lub hom phiaj ntawm ob qho kawg ntawm androgen receptor. Hauv cov qauv ua ntej, peb tau pom tias kev sib xyaw EPI-7386 nrog cov tshuaj tiv thaiv tam sim no tuaj yeem ua rau kom tob thiab dav inhibition ntawm androgen biology. Theem 1/2 kev sim no yog thawj zaug ntawm cov kev tshawb fawb soj ntsuam los soj ntsuam EPI-7386 ua ke nrog cov tshuaj antiandrogen tam sim no hauv cov neeg mob mCRPC, nrog rau Theem 1/2 txuas ntxiv kev sim xav tias yuav pib xyoo 2022. "

Theem 1/2 kev sim tshuaj ntsuam xyuas (NCT05075577) pib nrog thawj theem 1 feem nyob rau hauv cov koob tshuaj ntawm txhua cov tshuaj raug kho raws li theem 2 nyob rau hauv ib qho tshuaj enzalutamide piv rau kev sib xyaw ntawm enzalutamide thiab EPI-7386. Txoj kev tshawb fawb theem 1 yuav tsum tso npe mus txog 30 mCRPC cov neeg mob uas tseem tsis tau kho nrog cov tshuaj antiandrogen thib ob. Lub hom phiaj ntawm theem 1 ntawm txoj kev tshawb no yog txhawm rau ntsuas kev nyab xeeb thiab kev zam ntawm kev sib xyaw tshuaj thiab tsim kom muaj kev pom zoo rau theem 2 koob tshuaj EPI-7386 thiab enzalutamide thaum noj ua ke. Txoj kev tshawb fawb theem 2 yuav tsum tau tso npe rau 120 mCRPC cov neeg mob uas tseem tsis tau raug kho nrog cov tshuaj antiandrogen thib ob. Lub hom phiaj ntawm theem 2 ntawm txoj kev tshawb no yog txhawm rau ntsuas kev nyab xeeb, kev tiv thaiv kev tiv thaiv thiab kev tiv thaiv qog noj ntshav ntawm EPI-7386 ua ke nrog cov koob tshuaj tas li ntawm enzalutamide piv nrog enzalutamide ua ib tus neeg sawv cev.

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