Daim Ntawv Thov Tshuaj Tshiab Kev Kho Mob ntawm Cov Kab Mob Siab Tshaj Plaws

"Qhov kev tshem tawm ntawm peb daim ntawv thov IND rau NUV-868 yog qhov tseem ceeb tshaj plaws rau Nuvation Bio raws li nws yog qhov thib plaub IND hauv 14 lub hlis dhau los thoob plaws peb txoj kev sib sib zog nqus ntawm txoj kev kho mob qog noj ntshav uas tsom mus rau ntau hom qog nqaij hlav," said David Hung, MD, tus tsim. , tus thawj tswj hwm, thiab tus thawj coj ntawm Nuvation Bio. "Peb tau txais kev txhawb nqa los ntawm kev xaiv thiab qhov muaj peev xwm txhim kho kev zam tau pom los ntawm NUV-868 hauv kev tshawb fawb ua ntej, thiab peb cia siab tias yuav txhawb nqa txoj haujlwm mus rau theem 1 kev txhim kho nyob rau nruab nrab-2022."

NUV-868 inhibits BRD4, uas yog tus tswv cuab tseem ceeb ntawm tsev neeg BET uas tswj hwm cov proteins uas tswj cov qog loj hlob thiab sib txawv. NUV-868 yog tsim los kom muaj kev xaiv ntau dua rau BD2 dua li BD1 hauv kev sim kom tsis txhob muaj cov tshuaj txwv tsis pub muaj tshuaj lom ntawm lwm cov tshuaj tiv thaiv BRD4 xws li plab hnyuv (GI) thiab pob txha pob txha toxicities. Cov kev tshawb fawb hauv tsev kho mob tau pom tias NUV-868 yuav luag 1,500 lub sij hawm xaiv ntau dua rau BD2 dua li BD1. Tsis yog xaiv BD1 / 2 inhibitors hauv kev loj hlob tau cuam tshuam nrog cov teeb meem kam rau ua, muaj feem cuam tshuam vim BD1 inhibition ntau dhau.

Nrog rau kev tshem tawm ntawm IND no rau NUV-868 hauv cov qog nqaij hlav siab heev, Nuvation Bio yuav pib ua ntu 1/2 txoj kev tshawb fawb ntawm NUV-868 raws li kev kho mob monotherapy thiab ua ke nrog olaparib lossis enzalutamide hauv ntau hom qog. Cov txheej txheem no (NUV-868-01) yuav pib nrog Phase 1 monotherapy dose escalation kawm nyob rau hauv cov neeg mob qog nqaij hlav siab heev. Kev tshawb fawb Theem 1b yuav pib tshawb nrhiav NUV-868 ua ke nrog olaparib hauv yav dhau los kho mob zes qe menyuam, mob qog noj ntshav pancreatic, mCRPC, thiab TNBC cov neeg mob thiab ua ke nrog enzalutamide rau mCRPC cov neeg mob ua raws li Phase 2b txoj kev tshawb fawb ntxiv txog kev nyab xeeb thiab kev ua tau zoo. ib zaug pom zoo Phase 2 ua ke koob tshuaj raug txiav txim. Phase 2 txoj kev tshawb fawb monotherapy kuj tseem yuav pib rau hauv cov neeg mob mCRPC thiab txhawm rau tshawb nrhiav kev nyab xeeb thiab kev ua tau zoo.

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