Tshiab Antibody muaj peev xwm neutralizes Omicron thiab variants

Spike protein binding assays thiab neutralization assays siv cov kab mob uas sawv cev rau tag nrho cov paub txog SARS-CoV-2 variants ntawm kev txhawj xeeb (VOCs) tau ua tiav nrog STI-9167, thiab nAb no tau pom los khi nrog kev sib raug zoo siab thiab muab kev ua haujlwm tsis zoo (Omicron IC50). = 25 ng / ml). Ntawm qhov tseem ceeb, STI-9167 yog qhov tshwj xeeb thaum muab piv rau cov kev sim ntawm EUA-pom zoo SARS-CoV-2 nAbs nyob rau hauv cov khoom sib khi thiab nruab nrab yog khaws cia tawm tsam Omicron thiab Omicron (+R346K) variant, ib qho kev nthuav dav Omicron kab sib txawv ntau ntxiv. encodes ib qho ntxiv R346K Spike protein hloov pauv. Tsis tas li ntawd, STI-9167 tau tswj hwm ntawm koob tshuaj tsawg (5mg / kg) los ntawm txoj kev siv tshuaj intranasal lossis txoj hlab ntshav tau muab kev tiv thaiv zoo tiv thaiv cov tsos mob ntawm tus kab mob los ntawm Omicron variant hauv K18-hAce2 transgenic nas qauv ntawm COVID-19, tiv thaiv qhov hnyav. poob thiab txo tus kab mob titers hauv lub ntsws mus rau qib tsis paub meej.

Domenico Tortorella, PhD, xib fwb ntawm Microbiology ntawm Icahn Mount Sinai hais tias "Tib tiam thiab tus yam ntxwv ntawm STI-9167 nAb qhia txog kev sib koom tes zoo ntawm cov kws tshawb fawb ntawm Mount Sinai thiab Sorrento los daws qhov teebmeem kev noj qab haus huv thoob ntiaj teb,"

"Peb tau xaiv cov tshuaj tiv thaiv kab mob STI-9167 los ntawm ntau pawg ntawm ntau hom tshuaj tiv thaiv-SARS-CoV-2 spike neutralizing antibodies uas peb tau tsim hauv peb lub chaw sim. Nws tau pom tias muaj kev cuam tshuam zoo tshaj plaws rau txhua tus paub SARS-CoV-2 cais tawm thiab muaj kev txhawj xeeb sib txawv, suav nrog Omicron thiab Omicron (+R346K) tsis ntev los no, "hais lus J. Andrew Duty, PhD, Assistant xibfwb ntawm Microbiology thiab Tus Thawj Coj ntawm Center for Therapeutic Antibody Development ntawm Icahn Mount Sinai.

"Tam sim no EUA-pom zoo nAbs tau txo qis lossis tsis muaj kev cuam tshuam thiab kev ua haujlwm nruab nrab tiv thaiv omicron / omicron (+R346K) ua rau lawv tsis txaus los txhawb kev kho mob tam sim no," said Mike A. Royal, MD, JD, MBA, Tus Thawj Saib Xyuas Kev Kho Mob ntawm Sorrento. "Lwm yam nAbs xav tau mob heev nyob rau lub sijhawm ze, tshwj xeeb tshaj yog rau cov menyuam yaus uas zoo li muaj kev pheej hmoo siab dua rau kev kis mob omicron hnyav thiab mus pw hauv tsev kho mob. Peb cov txheej txheem intranasal COVIDROPS xa peb cov nAbs mus rau cov pa sab saud uas Omicron feem ntau yuav ua rau lub hom phiaj thiab vam meej, thiab raws li qhov tsis muaj kev cuam tshuam, yooj yim rau kev kho mob, nws yog qhov zoo tagnrho rau cov menyuam yaus. Peb twb tau pib kho cov menyuam yaus nrog KEVIDROPS (nrog STI-2099) hauv Mexico qhov chaw uas cov delta variant tseem muaj ntau. Los ntawm Theem 2 cov kev tshawb fawb hauv Asmeskas, United Kingdom thiab Mexico, peb tau pom cov ntaub ntawv muaj kev nyab xeeb zoo rau kev xa tawm ntawm peb nAbs thiab cia siab tias yuav muaj txiaj ntsig zoo sib xws nrog COVIDROP (nrog STI-9167).

"Tam sim no peb tau muaj kev paub txog kev coj ntau yam kev kho mob COVID-19 rau hauv tsev kho mob thiab nce ntau mus rau theem 2 thiab / lossis kev txhim kho tseem ceeb," said Mark Brunswick, PhD, SVP thiab Tus Thawj Saib Xyuas Kev Tswj Xyuas Kev Tswj Xyuas thiab Kev Ua Haujlwm Zoo ntawm Sorrento. "Peb tau nyob zoo kom coj tawm COVISHIELD sai sai dhau los ntawm theem IND thiab mus rau hauv tsev kho mob thiab cia siab tias yuav xa cov ntaub ntawv tseem ceeb no rau lub hli tom ntej."

Dr. Henry Ji, Thawj Tswj Hwm thiab CEO ntawm Sorrento tau hais tias, "Kev ua haujlwm los ntawm pab pawg ntawm Sorrento thiab Mount Sinai tau ua rau muaj cov tshuaj tiv thaiv zoo tshaj plaws nrog cov khoom muaj txiaj ntsig zoo tiv thaiv Omicron thiab tag nrho lwm yam SARS-CoV-2 VOCs. Peb COVISHIELD neutralizing antibody yog qhov zoo tshaj plaws-hauv-chav kawm thiab cov neeg sib tw siab tshaj plaws rau kev tawm tsam Omicron uas nthuav dav thiab tawm Omicron (+ R346K) VOCs. Peb tab tom mob siab ua haujlwm los muab cov tshuaj tiv thaiv kab mob no siv rau hauv cov neeg mob COVID thiab ntseeg siab tias peb txoj hauv kev yuav muab cov kev kho mob muaj txiaj ntsig tsis yog nyob rau lub sijhawm ze tab sis kuj yog qhov kev kis tus kabmob kis mus ntxiv. "

Daim ntawv sau ua ntej tau xa tuaj rau Lub Ib Hlis 19, 2022 thiab yuav tsum luam tawm sai sai hauv online ntawm biorxiv.org.

Cov tshuaj tiv thaiv tsis zoo uas tau piav qhia tau tsim nyob rau hauv cov chaw soj nstuam ntawm Mount Sinai thiab tsuas yog tso cai rau Sorrento Therapeutics. Mount Sinai thiab Mount Sinai cov kws qhia ntawv muaj kev txaus siab nyiaj txiag hauv Sorrento Therapeutics.

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