Promising New Anticancer Compounds

Nyob rau hauv tsab xov xwm tshuaj xyuas tsis ntev los no tau tshaj tawm hauv Kev Sib Koom Tes Tshuaj Ntsuam Xyuas, pab pawg kws tshawb fawb coj los ntawm xibfwb Chang Yeon Lee thiab Gajendra Gupta ntawm Incheon National University, Kaus Lim Qab Teb, tau tham txog kev hloov pauv thiab kev nce qib tsis ntev los no hauv kev ua haujlwm ntawm BODIPY-based MOCs thiab MOFs, nrog rau kev sib tham txog kev hloov pauv thiab kev nce qib tsis ntev los no hauv thaj chaw BODIPY tsom mus rau cov khoom sib xyaw ua haujlwm muaj peev xwm ua ob qho tshuaj tiv thaiv kab mob thiab cov cuab yeej rau kev tshawb fawb mob qog noj ntshav. Tsab ntawv piav qhia txog cov khoom sib txuas 'ntau yam zoo thiab kev sib koom ua ke nrog lwm yam kev kho mob thiab tseem hais txog cov kev txwv loj rau lawv daim ntawv thov dav.

Yog li, cov ntaub ntawv no yog dab tsi thiab dab tsi ua rau lawv zoo sib xws? MOCs thiab MOFs yog hlau complexes uas ua hauj lwm raws li ntau yam platforms mus rau uas tshiab functionalities yuav yooj yim qhia los ntawm kev hloov kho. Ob leeg tau siv dav hauv biomedicine thiab tau pom muaj peev xwm ua cov tshuaj tiv thaiv kab mob nrog kev xaiv zoo. Txawm li cas los xij, thaum BODIPY siv hauv MOCs lossis MOFs, cov khoom siv hluav taws xob ntawm cov khoom sib xyaw ua ke tuaj yeem raug kho kom ua tiav ntau yam teebmeem.

Ua ntej, BODIPY-raws li complexes yog zoo photosensitizing cov neeg ua hauj rau photodynamic kho, nyob rau hauv uas ib tug tshuaj yog activated los ntawm lub teeb los rhuav tshem lub hom phiaj hlwb. Thaum ua ke nrog MOCs lossis MOFs, qhov ua tau zoo ntawm cov complexes li tshuaj tiv thaiv kab mob nce ntxiv. Qhov thib ob, BODIPY-raws li complexes rhiab heev rau acidity (pH) ntawm nruab nrab. Vim hais tias qee cov qog nqaij hlav qog nqaij hlav yuav muaj pH qis (acidic), cov tshuaj no tuaj yeem tsim kho ntxiv kom tshwj xeeb rau cov qog nqaij hlav cancer hauv lub cev los ntawm kev siv cov txheej txheem no. Qhov kawg, tab sis tsis yog tsawg kawg, cov khoom fluorescent ntawm MOCs thiab MOFs tuaj yeem tsim kho kom lawv txoj haujlwm hauv hlwb tuaj yeem taug qab tau yooj yim siv cov txheej txheem fluorescence microscopy. "Qhov yooj yim tshaj plaws ntawm kev tsim kho BODIPY-raws li MOC / MOF cov tshuaj hauv cov tshuaj kho mob qog noj ntshav yuav pab cov kws tshawb fawb molecular thiab cell biologist nkag siab txog cov txheej txheem ntawm kev ua ntawm cov molecules tiv thaiv qog noj ntshav," piav qhia Prof. Lee.

Txawm hais tias qee qhov kev txwv ntawm BODIPY-based MOCs / MOFs, xws li kev siv sijhawm siv sijhawm thiab peb nkag siab tsis tiav ntawm nws cov tshuaj lom, cov tshuaj no tuaj yeem dhau los ua tus tseem ceeb hauv peb kev tawm tsam mob qog noj ntshav. "MOCs thiab MOFs tsim nrog BODIPY muaj tag nrho cov yam ntxwv tseem ceeb uas yuav tsum tau ua tus neeg sib tw tshuaj tiv thaiv kab mob zoo tshaj plaws," xaus lus Prof. Gupta. Nco ntsoov khaws lub qhov muag rau cov molecules siab heev thiab cov kev xav uas lawv yuav coj mus rau lub ntiaj teb kev kho mob qog noj ntshav thiab kev tshawb fawb.

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