Kev sim ua tau zoo rau Kev Kho Mob Cerebral Stroke Siv Tib Neeg Umbilical Cord Blood

Kev tshawb fawb Theem I tau ua rau cov neeg mob hnub nyoog 45-80 xyoo uas tau mob stroke ischemic stroke. Cov ntshav qaum cov hlab ntsha tau txais los ntawm StemCyte cov pej xeem qaum cov ntshav cov khoom muag raws li ABO / Rh ntshav hom, Human Leukocyte Antigen (HLA) match ntawm > 4/6, thiab ib koob ntawm tes ntawm tag nrho cov mononuclear cell (MNC) suav ntawm 0.5-5 x 107 cell / kg. Tsis tas li ntawd, plaub (4) 100 mL koob tshuaj ntawm mannitol tau txhaj tshuaj intravenously 30 feeb tom qab kev hloov ntshav hauv cov hlab ntsha thiab txhua 4 teev tom qab ntawd.

Cov txiaj ntsig tseem ceeb yog tus naj npawb ntawm cov neeg mob uas tsim cov kab mob graft tiv thaiv tus kab mob (GVHD) hauv 100 hnub tom qab tso ntshav. Cov txiaj ntsig thib ob tau hloov pauv hauv National Institutes of Health Stroke Scale (NIHSS), Barthel Performance index, thiab Berg Balance Scale cov qhab nia. Nyob rau hauv ib rooj plaub, ib tug txiv neej 46-xyoo-laus tus neeg mob uas muaj keeb kwm ntawm kub siab thiab hemodialysis rau lub raum theem kawg tau kho allogeneically siv hUCB nrog zoo tib yam ABO / Rh, ib tug 6/6 HLA match, thiab MNC suav ntawm 2.63 x 108. cell / kg. Tus neeg mob tsis tuaj nrog cov xwm txheej tsis zoo lossis GVHD thaum kawm 12 lub hlis. Nws cov qhab nia NIHSS poob ntawm 9 mus rau 1; Berg Balance Scale qhab nia tau nce los ntawm 0 mus rau 48, thiab Barthel Performance index tau nce los ntawm 0 mus rau 90. Qhov kev tshawb fawb ua ntej no tau pom tias tus neeg laus mob hemiplegia vim yog ischemic stroke tau zoo tag nrho hauv 12 lub hlis tom qab tau txais kev kho allogeneic UCB.

"Peb txaus siab heev rau qhov kev soj ntsuam tau zoo ntawm StemCyte's Phase I kawm," said StemCyte Thawj Tswj Hwm thiab Thawj Tswj Hwm Jonas Wang, PhD. "Nrog mob hlab ntsha tawg yog qhov thib ob thiab thib peb ua rau tuag thiab kev tsis taus, raws li, thoob ntiaj teb, qhov txiaj ntsig no zoo heev li nws tsis tau xav txog." Kwv yees li ntawm 30% -35% ntawm cov neeg uas raug mob stroke tuag thiab ze li ntawm 75% ntawm cov neeg muaj sia nyob muaj kev tsis taus mus tas li. Cov kev kho mob tam sim no nyob rau theem mob hnyav suav nrog kev siv thrombolytic, anticoagulant, thiab cov tshuaj tiv thaiv kab mob. Txawm li cas los xij, kev siv cov tshuaj no nce qhov tshwm sim ntawm hemorrhage los ntawm 15% -20%.

Cord ntshav qia hlwb proliferate mus rau hauv cov hlwb neural, thiab lawv tau pom tias muaj txiaj ntsig zoo hauv kev kho mob ntawm ntau yam kab mob neurodegenerative. Hauv kev mob hlab ntsha hlwb, kev txhaj tshuaj ntawm UCB thiab MNCs tuaj yeem rov ua kom muaj peev xwm ua haujlwm ntxiv nrog rau muab cov teebmeem neuroprotective raws li qhia los ntawm kev txo qis ntawm cov cim inflammatory xws li TNF-alpha, IL-1β thiab IL-2.

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